Thrombotic complications of COVID-19 and its relation with NADPH oxidase and tissue factor

Background: The severe acute respiratory syndrome corona-virus 2 (SARS CoV-2) is the virus responsible for disease 19 (COVID-19), a highly contagious and pathogenic viral illness. Individuals with illnesses may develop distress (ARDS) have altered coagulation functioning, which puts them at risk developing thromboembolic consequences. This work aimed to evaluate relation between NADPH oxidase (NOX2), tissue factor (TF) thrombotic complications in COVID-19 infection. Subjects: case-control was performed on 180 subjects. group included 100 patients proved be positive. Control 80 apparently healthy age sex matched subjects.Methods: Blood levels of NOX2, TF Interleukin-6 (IL-6) had been assessed by sandwich enzyme-linked immune-sorbent assay (ELISA) method.Results: substantial increase existed IL-6 events (TEEs) when compared control subjects without TEEs. ROC curve serum NOX2 predict showed sensitivity 96.55, specificity 94.37 positive predictive value 87.5. plasma 93.10, 92.96, 84.4.Conclusions: High oxidase2, are associated increased incidences complications, mortality rates admission ICU individuals COVID-19.